Dose Table
See Sialanar®’s dosing table in full.
From non-glycopyyronium bromide anticholinergics
Care should be taken when moving from another type of anticholinergic drug due to the potential for increased risk of anticholinergic adverse effects. There is no available data to support a direct dose conversion for patients changing from hyoscine/scopolamine or atropine to Sialanar®.1,2
A washout period from the first drug should be considered. Sialanar® should be prescribed following the dose table (please click this link to view the table), starting from dose level 1 and titrating in accordance with the SmPC to balance efficacy with undesirable effects.1
Please see the Dosing and Titration Page for further information on initiating Sialanar®
The half-life of free scopolamine is approximately 10 hours so the drug should be cleared within about 3 days. However, it is the clinicians responsibility to decide when the new medicine should be started following the withdrawal of the previous medicine.2
From generic glycopyrronium bromide oral solutions:
Glycopyrronium bromide (GB) tablets and oral solutions are not interchangeable on a microgram-for-microgram basis due to differences in bioavailability. Sialanar® oral solution has approximately 25% higher bioavailability and therefore equivalent doses will be lower than for tablets and generic oral solutions.3
Care should be taken if switching between oral preparations and dosing adjusted accordingly.
Please click on the the button below to see the dose conversion guidance to Sialanar, from either the generic 1mg/5ml GB products or the 2mg/5ml GB generic product1,4-7
Safety
Head to this section for guidance on side effects and titration.
Clinical Evidence
The first and only double-blind, randomised, placebo-controlled study of oral anticholinergics in sialorrhoea that has investigated efficacy, safety and impact on quality of life,8,9 continued as an open-label study extension (OLSE)9 . Find out more