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See the SALIVA Trial - The first and only double-blind, randomised, placebo-controlled study of oral anticholinergics in sialorrhoea 
that has investigated efficacy, safety and impact on quality of life
2 continued as an open-label study extension3

Sialanar is Designed for Children

Tailored titration for flexible and accurate dosing1

Due to a greater bioavailability, Sialanar® dose volumes are 20% lower than other glycopyrronium bromide oral solutions of the same concentration (2mg/5ml),1,4,5 helping to improve patient acceptability6

Minimal excipients to reduce toxicity risk - sugar, alcohol and sorbitol free1,7,8

Use the links below to explore

  • About Sialanar®

    Sialanar® is designed for children, learn more about its features and why they make a difference. Find out more

  • Dosing and Titration

    Head to this section to find out more about the dosing and titration schedule for Sialanar®. Find out more

  • Clinical Evidence

    The first and only double-blind, randomised, placebo-controlled study of oral anticholinergics in sialorrhoea that has investigated efficacy, safety and impact on quality of life2,3 continued as an open-label study extension (OLSE)3 Find out more

  • Safety

    Head to this section for guidance on side effects and titration.

    Find out more

     

  • Resources

    Visit the resources section to find product support materials for patients/carers and educational resources for healthcare professionals. Find out more

  • Why treat drooling?

    Did you know one population study found pneumonia is responsible for 39% of deaths in children with cerebral palsy.9

Sign up for Proveca Education Events

Proveca run educational sessions on a regular basis covering a variety of topics, register here by completing our 'contact us' form to be the first to know what’s coming up or head to our resources section to catch up on previous sessions.

References

  1. Sialanar® SmPC (August 2026) https://www.medicines.org.uk/emc/product/2301 
  2. Fayoux P et al., Glycopyrronium 320 μg/mL in children and adolescents with severe sialorrhoea and neurodisabilities: A randomized, double-blind, placebo-controlled trial. Developmental Medicine & Child Neurology 2024; 00: 1–9. DOI:10.1111/dmcn.15841. https://onlinelibrary.wiley.com/doi/10.1111/dmcn.15841 
  3. Fayoux P, et al. Glycopyrronium 320 μg/mL in children and adolescents with severe sialorrhoea and neurodisabilities: An open-label study extension of the SALIVA trial. Dev Med Child Neurol. 2025; 00:1–10.DOI: 10.1111/dmcn.16251  
  4. BNFC Glycopyrronium Bromide https://bnfc.nice.org.uk/drugs/ glycopyrronium-bromide/.
  5. Glycopyrronium Bromide 2mg/5mL Oral Solution (Colonis Pharma Ltd.) SmPC.(January 2026) Available at: emc.medicines.org.uk
  6. Batchelor H & Marriot J. BJCP 2015. Formulations for Children: Problems and Solutions https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.12268 
  7. Rouaz K, et al. Excipients in the paediatric population: a review. Pharmaceutics 2021; 13(3): 387.
  8. Arthur S. How to identify and manage ‘problem’ excipients in medicines for children. The Pharmaceutical Journal 2017. Available at:https://pharmaceutical-journal.com/article/ld/how-to-identify-and-manage-problem-excipients-in-medicines-for-children
  9. Reddihough, D et al. Cerebral palsy in Victoria, Australia: Mortality and causes of death. J of Paediatr and Child Health 2021, 37: 183-186

All reference links accessed August 2026.

UK-SIA-26-0019 | August 2026

Adverse Event Reporting Information

UK: Adverse events should be reported. Reporting forms and information can be found at: www.mhra.gov.uk/yellowcard

Adverse events should also be reported to Proveca Limited. Phone: +44 333 200 1866 E-Mail: medinfo@proveca.com

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