About Sialanar^®

• The dose volume is a major consideration for the acceptability of a liquid formulation⁶
• The maximum recommended single dosing volume for paediatric liquid formulations for typically developing children is <5ml for children under 5 years and <10ml for children of 5 years and older⁵
• Initial research suggests even Cerebral Palsy patients at EDACs level I may have a reduced dysphagia limit in comparison to typically developing children, with a median of 7ml.¹⁰
• Eating, drinking and swallowing difficulties (dysphagia) are common in children with neurodisability⁶

Sialanar^® is designed for children and has the lowest volumes for equivalent doses of any licensed glycopyrronium bromide oral solution.^1-4

• Excipients are a necessary component of almost all medicines, but they may be present in quantities which are potentially harmful to babies and children⁶
• Excipients used in adult formulations may not be appropriate for paediatric use so have the potential to lead to adverse effects⁸
• Oral doses of sorbitol which are greater than 140mg/kg/day may result in increased gastrointestinal (GI) side effects, including osmotic diarrhoea, abdominal pain, bloating and GI discomfort^7,8

Watch the excipients animation

Sialanar^® is designed for children, using sucralose as a sweetener instead of sorbitol^2,3,4 and is suitable for patients on a ketogenic diet (<5mg/ml carbohydrate)^1,11

Sialorrhoea can cause significant clinical problems and negatively impact quality of life for patients and carers^12,13

Physical consequences

• Posterior sialorrhoea: can lead to aspiration, increasing the risk of respiratory infections, hospitalisations and mortality^14-16

• Anterior sialorrhoea: can cause infections, macerated skin, interference with feeding and dehydration¹³
  
  

• Aspiration can develop silently so may not be diagnosed prior to development of more serious lung issues¹⁴

• Respiratory illness is the leading cause of hospitalisations and mortality in young people with cerebral palsy, 25% of patients (4-5 GMFCS) suffer from chronic respiratory problems^16,17
  

Management of sialorrhoea is recommended to reduce risk factors for aspiration, helping to prevent further respiratory illness¹⁵

Psychosocial concerns

• Social embarrassment, isolation and low self-esteem
• Increased dependency and level of care
• Barriers to education (damage and inability to share books / computers)